The human body has an endocannabinoid system — a natural system that maintains homeostasis or balance, in the body. The endocannabinoid system has CB1 and CB2 receptors. These are found throughout the body. CB1 receptors are generally located in the central and peripheral nervous system and CB2 receptors are generally found in the brain, immune system, and gastrointestinal system. CBD binds to these receptors creating changes and effects in the body
Also, all HempWorx products are 100% organic and non-genetically modified, and the company apparently makes all of its products right here in the United States. Moreover, the hemp used to extract the oil is grown in Kentucky, and unlike a lot of firms who claim their CBD products to be lab tested, HempWorx actually ‘walks the walk’ by publishing up-to-date details of their test results on the site (you can find them under the “HempWorx Store” tab by clicking the “CBD Oil Certification” button).

This is the second time Moon Mother Hemp Company has placed among the top five brands on our ranking. The Colorado-based company, which was founded about a year ago, sets the bar very high for quality (including USDA-certified organic hemp) without charging the moon for its products. Their tinctures taste so good, you may be sad you don’t need more.  


If you’re ready to get your CBD on, picking any of these high-quality vape liquids will give you the best possible introduction to this wildly popular substance. The VaporVanity editorial team has verified that these are some of the best CBD vape oils on the market today, so you can rest easy knowing that as long as you choose from this list, any choice you make is certain to be a good one.
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Disclaimer: This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited by Law.
Vape oil: CBD vape oil is used for vaping CBD. This requires the use of an e-cigarette or vape pen, which can have side effects when chemicals are heated to high temperatures. There are also CBD waxes available that are used for dabbing the cannabis compound. This also requires heating a small amount of the wax and using a dabbing pen. This isn’t recommended for beginners, as it’s usually a higher concentration of CBD.
Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.
Unlike NSAIDs, many doctors believe that acetaminophen does not increase your risk of stomach or heart issues. They are often recommended to those whose stomach cannot tolerate NSAIDs well. However, acetaminophen is far from ideal for your body. The long-term use and overuse of acetaminophen have been linked to liver problems and acute liver failure.
Cannabis oil preparations have been used historically in medicine for millennia. Only recently, cannabis and chemically-related compounds have come back to being considered of beneficial value. A prominent compound found in cannabis, CBD, or cannabidiol, has been shown to have some benefits. What is CBD oil good for? Find out all about CBD, including the extensive CBD oil benefits list, CBD oil uses and the many different CBD oil forms.
‘I recommend starting with a low dose and slowly building up over a few weeks, to find the dose that works best for you,’ agrees Dr Brewer. ‘For example, start with Healthspan High Strength CBD Oil 6.4mg Capsules, taking one to three daily. Then, if needed, move up to Super Strength CBD 15mg Capsules, taking one to two daily. CBD is not psychoactive and is not addictive. I prefer capsules, as CBD drops have a strong taste, although filter-clear peppermint flavoured drops are available.’
In addition to acting on the brain, CBD influences many body processes. That’s due to the endocannabinoid system (ECS), which was discovered in the 1990s, after scientists started investigating why pot produces a high. Although much less well-known than the cardiovascular, reproductive, and respiratory systems, the ECS is critical. “The ECS helps us eat, sleep, relax, forget what we don’t need to remember, and protect our bodies from harm,” Marcu says. There are more ECS receptors in the brain than there are for opioids or serotonin, plus others in the intestines, liver, pancreas, ovaries, bone cells, and elsewhere.
CBD is readily obtainable in most parts of the United States, though its exact legal status is in flux. All 50 states have laws legalizing CBD with varying degrees of restriction, and while the federal government still considers CBD in the same class as marijuana, it doesn’t habitually enforce against it. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. Currently, many people obtain CBD online without a medical cannabis license. The government’s position on CBD is confusing, and depends in part on whether the CBD comes from hemp or marijuana. The legality of CBD is expected to change, as there is currently bipartisan consensus in Congress to make the hemp crop legal which would, for all intents and purposes, make CBD difficult to prohibit.
It’s safe to say that Charlotte’s Web is probably the most recognized CBD brand out there — and it’s not all hype. This company pioneered the CBD industry and made it their mission to de-stigmatize CBD by setting the bar high for transparency. They produce and oversee their organic CBD products from seed to sale, standing behind them with a solid return policy. 
While CBD and marijuana have been used for centuries for many remedies, the role CBD can play in lessening the severity and number of seizures in those diagnosed with epilepsy came into the spotlight in the early 2000’s. That’s when the Figi family began looking for a way to treat their daughter Charlotte’s seizures. At the time, she was suffering upwards of 300 seizures per week. (8)

After consulting with Amanda Chantal Bacon of Moon Juice, I decided to invest in a bottle of Gone Green Hemp CBD Oil in the 500mg tincture. Gone Green is a really incredible company that only sources the best herbs, adaptogens, and superfoods, so I knew I would be getting a very high-quality product when I grabbed their bottle off of Moon Juice’s shelf. You can buy Gone Green’s Hemp CBD Oil online—it’s 100% legal in all 50 states. They have the best customer service ever, and they carry tons of other fantastic products that any health-conscious person would love!


However, before the villainization of hemp, it was widely accepted as a very useful plant (3). From biofuel from its seeds to medicine from its leaves, it ought to be a core crop grown by farmers across the United States and beyond. However, for reasons too numerous to discuss in this article, issues of legality and federal restrictions have put a stop to that idea for the time being.
Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.

Although the HempWorx ‘About Us’ page is filled with excellent information on the history of CBD, there is unfortunately little data about the actual organization itself. We did learn, however, that they use “special” supercritical technology that extracts over 400 phytonutrients from the raw hemp material, and that they don’t use any harmful solvents or heat, which is of course a good thing.
One brand of CBD oil I fully trust and highly recommend to my patients, readers, friends, and family is Rooted Apothecary. They are committed to creating a piece of the puzzle towards a better, healthier life for you and your family. Their products are full spectrum hemp extract grown with love on an organic farm in Colorado, and they are independently tested to ensure safety and quality.
I stopped by Moon Juice after work, feeling a little nervous and excited all at once. “You might notice that your body feels a bit heavy after you try it—sometimes when I take it I feel like I just want to sit down and chill,” said the women behind the Moon Juice counter who helped me. Prepped for potential side effects, I emptied one dropper’s worth of CBD oil into my chamomile tea as soon as I got home … And didn’t feel anything. A few hours later I got into bed and immediately fell asleep.
The 600 mg oil is a good “step-up” option for people who find that they’re having to take large (and/or multiple) doses of the 300 mg in order to get effective results. In general, a lot of people use this strenght for more moderate cases of anxiety, pain, inflammation, and digestive issues. A single dose is still the same 15 drops of oil, but instead of containing 7.5 mg of CBD, a 600 mg bottle will contain 15 mg per dose.
When administered alone, CBD is an effective anticonvulsant in maximal electrical shock (MES), magnesium-free, 4-aminopyridine, and audiogenic models (7, 8). Co-administration with AEDs leads to various effects; anticonvulsant effects of CBD are enhanced with phenytoin or phenobarbital but decreased with chlordiazepoxide, clonazepam, trimethadione, and ethosuximide. In a recent study using an acute pilocarpine model, although CBD administration reduced the number of animals displaying seizure activity, CBD did not appear to have any significant effect on the number of seizures per animal (7).
CBD is the major non-euphorigenic component of Cannabis sativa. Some research is beginning to show that CBD is different than other well-studied cannabinoids. All cannabinoids function as ligands, meaning they dock onto the binding site of a protein and have the ability to modulate a receptor’s behavior. CB1 receptors are widely distributed, but are particularly abundant in areas of the brain, including those concerned with movement, coordination, sensory perception, emotion, memory, cognition, autonomic and endocrine functions.
Scott Shannon, MD, assistant clinical professor at the University of Colorado, recently sifted through patient charts from his four-doctor practice to document CBD’s effects on anxiety. His study, as yet unpublished, found “a fairly rapid decrease in anxiety scores that appears to persist for months,” he says. But he says he can’t discount a placebo effect, especially since “there’s a lot of hype right now.”
Hemp oil does have a number of uses and is often marketed as a cooking oil or a product that is good for moisturizing the skin. It is also used in the production of certain soaps, shampoos, and foods. It is also a basic ingredient for bio-fuel and even a more sustainable form of plastic. Hemp has been cultivated and used for roughly 10,000 years, and it definitely has useful purposes. However, a lack of cannabinoids, namely CBD, means that it has little therapeutic value.
Improving the appearance of the skin, especially reducing the signs and symptoms of acne and eczema, are the great benefits of regular CBD oil use. Topical application is quite popular for this, whether in a diluted or undiluted form, depending on the severity of the skin affliction. The powerful anti-inflammatory properties of the oil can also soothe redness, itchiness, and swollen areas of the skin.
As is the case with any plant that constitutes a crop, cannabis plants have been selectively bred over the years to bolster one or another desired characteristic. This means that some plants provide a more potent psychotropic effect, others possess more prominent seeds (used in the production of cooking oil traditionally), while others may make for sturdier textile fibers.
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