Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
More recent experiments, involving the administration of a part CBD part THC solution, have yielded results that contradict the first supposition. At present, on the evidence that cannabidiol reduces some of the psychoactive effects of tetrahydrocannabinol (acting as a de facto antidepressant), scientists argue that cannabidiol has a holistic but indirect influence on all cannabinoid receptors in the endocannabinoid system. The main consequence of this impact seems to be an increase in the production of endocannabinoids. This is now the prevailing idea that accounts for the mountains of empirical evidence of how the benefits of cannabidiol are expressed at the cellular level.

Hemp oil (also called hemp seed oil) is extracted from the hemp seeds of the hemp plant and it contains very little or no THC. Cannabis, on the other hand, has THC levels above 0.3 percent (usually between 5-35 percent). Because of its low THC levels, you can use hemp oil without feeling “high” afterwards. Hemp is typically grown for industrial purposes, as it’s used to make clothing, paper, ropes, carpets, construction materials and plastic composites.

It all starts with the connection between the endocannabinoid system and intestinal function/motility. Recent studies have found that the transmitters regulated by the endocannabinoid system are located throughout the human body. Some of these transmitters are responsible for gut function; when imbalanced, negative effects are likely to occur. (41)
The amount of milligrams of CBD you should take depends on your specific reason for taking CBD. If you are using CBD to treat chronic pain, you might take a much higher dose than someone who would be using CBD for general wellness reasons. Google search for your specific condition or reason for taking CBD to find the dose that is appropriate for you. You can take CBD in high qualities, so feel free to test out different dosages and see how your body reacts. A standard dose of CBD is 10 mg once a day, but this varies so widely because each individual is different so this can’t be taken as a recommendation for you.
Cannabidiol pharmacological effects are mediated through G protein coupled receptors, cannabinoid type I (CB1) and cannabinoid type II (CB2), which are highly expressed in the hippocampus and other parts of the central nervous system (2). When activated, CB1 receptors inhibit synaptic transmission through action on voltage-gated calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3). CB2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system. The effects of CBD are CB2 receptor independent (3).
It’s thought that the endocannabinoid system may be critical for regulating sleep and sleep stability, which make sense, as it promotes balance throughout the body. Research seems to show that when CBD interacts with this system, sufferers may achieve longer periods of overall sleep. Furthermore, earlier research demonstrated that CBD may provide relief for insomnia sufferers who struggle to achieve REM sleep due to anxiety. (33, 34, 35) 

Nevertheless, as populations age all across the globe, constant pain brought on by chronic illnesses in the elderly will surely become a matter of public health and compassion. A 2008 study inquired on the efficacy of cannabinoids other than THC in pain management. Painkillers with cannabinoids proved to be well tolerated, with minimum side-effects, and a prospect for low long-term toxicity. Furthermore, a combination of cannabidiol and opioids is thought to be the breakthrough of the future in palliative care.[24]

Unlike NSAIDs, many doctors believe that acetaminophen does not increase your risk of stomach or heart issues. They are often recommended to those whose stomach cannot tolerate NSAIDs well. However, acetaminophen is far from ideal for your body. The long-term use and overuse of acetaminophen have been linked to liver problems and acute liver failure.
CBD is suddenly everywhere — and it’s not hard to see why. It won’t get you high, has a good safety profile, and naturally treats dozens of conditions. But there’s a dizzying amount of choice out there, so we’ve ranked the 25 best CBD oils to help you get started. Whether you’re a rank beginner, or you’ve been experimenting with CBD for a while, we’ve got you covered.
All this talk about THC lands us nicely in the whole “Full Spectrum vs. Pure Isolate” debate. Once you begin shopping for CBD products, you’ll notice a lot of jargon that gets thrown around without much explanation. Now that we’ve introduced THC into the conversation, we can talk about the difference between, and relative benefits of, Full Spectrum CBD and CBD Isolate (and the lesser-known contender: Broad Spectrum).
The way NSAIDs work is by blocking the Circulating Immune Complex (CIC) activity in your body. CIC is a protein chain activated by your immune system causing pain, swelling, and redness to promote recovery. However, instead of affecting only the CIC around your pain, NSAIDs affect all CICs in your body, including ones that are necessary to maintain the lining of your stomach, intestines, liver, and kidneys. Long-term use of NSAIDs can result in more pain, stomach ulcers, kidney and liver toxicity, and leaky gut syndrome. Long-term they may lead to kidney and liver damage, intestinal bleeding, and even death (8, 9, 10, 11, 12).

However, before the villainization of hemp, it was widely accepted as a very useful plant (3). From biofuel from its seeds to medicine from its leaves, it ought to be a core crop grown by farmers across the United States and beyond. However, for reasons too numerous to discuss in this article, issues of legality and federal restrictions have put a stop to that idea for the time being.

By commenting on this post I agree to give source information for any health/medical information that is not my personal experience or general knowledge. I understand that personal experience is any symptom, test, treatment, etc. that I or a close family member has undergone himself/herself. I understand that my comment will not be approved unless I provide trustworthy sources for all statements regarding statistics, data, studies, and new advancement in medicine.


When administered alone, CBD is an effective anticonvulsant in maximal electrical shock (MES), magnesium-free, 4-aminopyridine, and audiogenic models (7, 8). Co-administration with AEDs leads to various effects; anticonvulsant effects of CBD are enhanced with phenytoin or phenobarbital but decreased with chlordiazepoxide, clonazepam, trimethadione, and ethosuximide. In a recent study using an acute pilocarpine model, although CBD administration reduced the number of animals displaying seizure activity, CBD did not appear to have any significant effect on the number of seizures per animal (7).
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
37. Johnson, JR, Burnell-Nugent, M, Lossignol, D, Ganae-Motan, ED, Potts, R, Fallon, MT. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage. 2010 Feb;39(2):167-79. PMID: 19896326
One of the natural ways to find relief from pain and to increase your overall health that I’m incredibly excited about is CBD oil. The use of CBD oil may help you to find relief from a variety of pain, including fibromyalgia, headaches, arthritis pain, menstrual cramps, muscle pain, and cancer pain. It may be incredibly beneficial for your health on a variety of other ways, such as reducing depression and improving your sleep.
Hemp oil (also called hemp seed oil) is extracted from the hemp seeds of the hemp plant and it contains very little or no THC. Cannabis, on the other hand, has THC levels above 0.3 percent (usually between 5-35 percent). Because of its low THC levels, you can use hemp oil without feeling “high” afterwards. Hemp is typically grown for industrial purposes, as it’s used to make clothing, paper, ropes, carpets, construction materials and plastic composites.
Current studies, including one carried out by the UC San Diego School of Medicine, are looking into how the endocannabinoid system may be linked to reducing symptoms associated with autism. This is due to its role in social reward responsivity, neural development and circadian rhythm and anxiety regulation – all of which are often affected by autism. (52)
Cannabidiol pharmacological effects are mediated through G protein coupled receptors, cannabinoid type I (CB1) and cannabinoid type II (CB2), which are highly expressed in the hippocampus and other parts of the central nervous system (2). When activated, CB1 receptors inhibit synaptic transmission through action on voltage-gated calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3). CB2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system. The effects of CBD are CB2 receptor independent (3).
‘The media has no doubt helped drive this popularity,’ says Dr Sarah Brewer, medical director at Healthspan. ‘However, the main drive is because people who take it experience the benefits very quickly, and “word of mouth” is a powerful thing. CBD oil also has such a wide range of benefits, reducing anxiety, promoting relaxation, ensuring a good night’s sleep, reducing pain perception and improving general feelings of wellbeing. It therefore appeals to a wide range of people.’

Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.

After consulting with Amanda Chantal Bacon of Moon Juice, I decided to invest in a bottle of Gone Green Hemp CBD Oil in the 500mg tincture. Gone Green is a really incredible company that only sources the best herbs, adaptogens, and superfoods, so I knew I would be getting a very high-quality product when I grabbed their bottle off of Moon Juice’s shelf. You can buy Gone Green’s Hemp CBD Oil online—it’s 100% legal in all 50 states. They have the best customer service ever, and they carry tons of other fantastic products that any health-conscious person would love!
All this talk about THC lands us nicely in the whole “Full Spectrum vs. Pure Isolate” debate. Once you begin shopping for CBD products, you’ll notice a lot of jargon that gets thrown around without much explanation. Now that we’ve introduced THC into the conversation, we can talk about the difference between, and relative benefits of, Full Spectrum CBD and CBD Isolate (and the lesser-known contender: Broad Spectrum).
CBD oil has numerous proven health benefits. Whether you’re looking to treat your anxiety, depression, chronic pain, insomnia, or just want to feel more focused and relaxed; then CBD oil (or gummies, dabs, or a pre-filled vape pen) is the perfect choice. They even make CBD dog treats so your furry friend can get the benefits. This CBD stuff is the real deal.

CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
The human body has an endocannabinoid system — a natural system that maintains homeostasis or balance, in the body. The endocannabinoid system has CB1 and CB2 receptors. These are found throughout the body. CB1 receptors are generally located in the central and peripheral nervous system and CB2 receptors are generally found in the brain, immune system, and gastrointestinal system. CBD binds to these receptors creating changes and effects in the body
The inquiry upon the manner in which THC produces its psychoactive effects on the human body led, in the 1980’s, to the discovery of the endocannabinoid system – a rather loose complex of nerve receptors which under the influence of compounds called cannabinoids trigger many physiological and psychological reactions. Because cannabinoid receptors are present in almost every tissue of a mammal’s body (although they are not limited to mammals), it has wide-ranging influences on the well-being of an organism. Therefore cannabinoids are definitely substances that deserve further attention from scientists.
Another major reason why CBD oil has been positively received in some parts of the medical community is its apparent effect on cancer and tumor growth.A study done by the researchers of the Institute of Toxicology and Pharmacology, University of Rostock, Germany recommends the use of CBD oil (even direct injection into tumors) to eliminate or reduce the size of the tumors. The antioxidants in CBD hemp oil also provide anti-mutagenic properties and lower users’ risk of cancer.
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