For some people, however, regular strength CBD just doesn’t cut it. If you’re one of those people, you may require something a lot stronger. If you think that CBD “doesn’t work”, then it’s possible that you might need to step it up to something stronger. Whether you’ll be good with a 1000mg high-strength CBD oil or if you need to step up to the big leagues with the Hemp Bombs 4000mg vape juice is a matter of personal preference. Everyone’s body is different. What works for someone else may not work for you. Experiment and find the perfect dosage that works best for your unique needs.
Furthermore, this number is expected to grow. According to the CDC, it is estimated that by 2040, over 78 million adults will have arthritis that has been diagnosed by a doctor, with 43% of those individuals limited in terms of activity because of the disease, without taking into effect other conditions that contribute to arthritis side effects, like growing obesity numbers and more.

The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.
For the past couple of years, the field has been experiencing a boom in cannabidiol-related research. What has permeated the scientific consensus stems from efforts undertaken to explain effects of THC, with descriptions of cannabidiol just a by-product of the initial purpose. For example, CBD was thought to have been simply a precursor of THC, mainly due to the structural similarities between the two.
CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
Naturally, the testimonies of these experts were based on a comprehensive literature review, an endeavor which we have also undertaken, albeit in a less official capacity. While many new products have been hailed as a panacea in their times, and many web sources certainly allude to this status for CBD, our objective was more modest – presenting ten possible benefits of cannabidiol where sufficient evidence exists to back up the claims.
CBD affects the endocannabinoid system, which has cannabinoid receptors throughout the human body. That’s one of the major reasons why CBD’s therapeutic properties include pain relief. The cannabinoid receptors are connected to the human nervous system.  CBD affects some of them (not CB1 and CB2 which are activated by THC) and a  neural connection is triggered in the brain.

Pioneers of the CBD industry, 4 Corners Cannabis helped pave the way for companies that want to provide quality products and utilize best practices. They grow their own strain of hemp and make small batches of true full-spectrum CBD products. Their prices place them lower down on our ranking, but their highly satisfied customers are more than willing to pay for the 4 Corners quality.  


Although the HempWorx ‘About Us’ page is filled with excellent information on the history of CBD, there is unfortunately little data about the actual organization itself. We did learn, however, that they use “special” supercritical technology that extracts over 400 phytonutrients from the raw hemp material, and that they don’t use any harmful solvents or heat, which is of course a good thing.
Conventional treatment options are not only expensive but often ineffective. Pain medications comes with side effects, health risks, and toxicity that may lead to further pain and health issues. It is often safer and more effective to try natural methods of pain relief, such as an anti-inflammatory diet, stress-reduction strategies, exercise, and bodywork.
The 600 mg oil is a good “step-up” option for people who find that they’re having to take large (and/or multiple) doses of the 300 mg in order to get effective results. In general, a lot of people use this strenght for more moderate cases of anxiety, pain, inflammation, and digestive issues. A single dose is still the same 15 drops of oil, but instead of containing 7.5 mg of CBD, a 600 mg bottle will contain 15 mg per dose.
A study highlighting this was performed approximately one decade ago. The study found a link between IBS sufferers and clinical endocannabinoid deficiency, which relates back to the fact that the system directly impacts intestinal motility and function. When CBD was used to activate and regulate the endocannabinoid system, sufferers of IBS saw significant symptom improvement. (42)
Although the HempWorx ‘About Us’ page is filled with excellent information on the history of CBD, there is unfortunately little data about the actual organization itself. We did learn, however, that they use “special” supercritical technology that extracts over 400 phytonutrients from the raw hemp material, and that they don’t use any harmful solvents or heat, which is of course a good thing.

Transparency: Moon Mother sends each batch of product to a third-party lab to be tested for potency as well as other contaminants. You can find all of these lab reports on the company’s website. They also added more information about their company processes to the website, so it’s easier to find important information about extraction and manufacturing.
Customer Service: It’s difficult to find contact information on Calm by Wellness’s website, and their email address is listed incorrectly in two places (we tried sending them an email but it was not delivered). We were, however, able to get a response through Facebook, and the company does offer free shipping and a generous 30-day return policy on all orders.

A study published by David Cheng, Postdoctoral Scientist, Neuroscience Research, University of New South Wales, NSW, Australia, says that CBD has a potential as a preventive measure against symptoms of Alzheimer’s. This presents yet another exciting development for medical researchers, given the persistent challenges to finding effective solutions for this condition.


ADHD, or attention deficit disorder, with or without hyperactivity, is often first noticed and diagnosed in school-aged children (it is the most commonly diagnosed neurodevelopmental disorder of childhood). Many sufferers must learn to adapt to difficulties in paying attention, remembering seemingly simple tasks, being over-compulsive and more, over the long term. (44)
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
CBD hemp oil has a number of uses and comes in many forms including capsules, tinctures, sublingual supplements, liquid oil, oil as a paste, sprays, salves, creams and in edible forms, such as candies or sweets. You can also inhale CBD oil from vapor-releasing pens, similar to the technology for e-cigarettes. This variety also provides a lot of controlled flexibility in terms of concentration, making CBD hemp oil useful and desirable for people of all ages, economic means, and personal needs.
At present, we have the following classification of cannabinoids: endocannabinoids (produced naturally in the body, mainly from fatty acid precursors), phytocannabinoids (compounds that have a plant origin, with the cannabis plant being the best-studied source of phytocannabinoids though not the only one), and artificial cannabinoids (created while studying THC, to garner the benefits of marijuana without the recreational component).
“Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
Nevertheless, as populations age all across the globe, constant pain brought on by chronic illnesses in the elderly will surely become a matter of public health and compassion. A 2008 study inquired on the efficacy of cannabinoids other than THC in pain management. Painkillers with cannabinoids proved to be well tolerated, with minimum side-effects, and a prospect for low long-term toxicity. Furthermore, a combination of cannabidiol and opioids is thought to be the breakthrough of the future in palliative care.[24]
When it comes to using CBD, questions keep coming up, especially from people who try CBD for the first time. Since there are different CBD products and because CBD can be used in different ways, the question of how to use CBD oil is quite legitimate.  What CBD products are available, how they can be used, and the bioavailability of each product is covered in this article.
Consume CBD oil if you want to quit smoking cigarettes. While consuming CBD oil, people sometimes report craving nicotine less. Withdrawal symptoms like anxiety and mood swings also aren’t as severe for many people when they take CBD oil. If you’re struggling to quit smoking cigarettes, try using CBD oil to potentially diminish your cravings and withdrawal symptoms.[13]

THC does typically come with a long list of health benefits, but the clinical use of this cannabis compound is often limited by its unwanted psychoactive side effects in people. For this reason, interest in non-intoxicating phytocannabinoids, such as CBD, has substantially increased in recent years. In fact, CBD is being used in conjunction with THC for more favorable effects.
Using rigorous review methodology, Gloss and Vickery conclude that based on the low quality of the reports available, there is insufficient data available to draw any conclusions regarding the efficacy and or long-term safety of CBD in treating epilepsy (11). From the data available, it does appear that daily doses of 200 to 300 mg were safe in this small group of patients for a short period of time (14).
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
Social media is blasting this one out lately, showing that different parents have been treating their children illegally (in states that are not classed as medical states) to help prevent their children from having seizures or deal with epilepsy. While there has been limited scientific evidence on the topic, 2016 was a major turning point for the plant as a major study was conducted by Orrin Devinsky, a neurologist at New York University Langone Medical Center, showing profound results.
Naturally, the testimonies of these experts were based on a comprehensive literature review, an endeavor which we have also undertaken, albeit in a less official capacity. While many new products have been hailed as a panacea in their times, and many web sources certainly allude to this status for CBD, our objective was more modest – presenting ten possible benefits of cannabidiol where sufficient evidence exists to back up the claims.
‘The media has no doubt helped drive this popularity,’ says Dr Sarah Brewer, medical director at Healthspan. ‘However, the main drive is because people who take it experience the benefits very quickly, and “word of mouth” is a powerful thing. CBD oil also has such a wide range of benefits, reducing anxiety, promoting relaxation, ensuring a good night’s sleep, reducing pain perception and improving general feelings of wellbeing. It therefore appeals to a wide range of people.’

CBD is a chemical found in marijuana. CBD doesn't contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The usual CBD formulation is oil, but CBD is also sold as an extract, a vaporized liquid and an oil-based capsule. Food, drinks and beauty products are among the many CBD-infused products available online.
“Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
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